Current Issue : July-September Volume : 2013 Issue Number : 3 Articles : 1 Articles
Cataractogenesis is one of the earliest complications of diabetes mellitus. Problems that might initially trigger the formation of cataracts include too much glucose inside the lens, high doses of radiation, injuries that penetrate the lens and the long term use of certain drugs. The only available treatment for this affliction is surgical removal. In the present study effect of CYP450 inducer (Pioglitazone) & CYP450 inhibitor (Diltiazem) on protein content of lens in diabetic rat as an experimental model Male Sprague-Dawley suckling rats (18 days; 40-50 gms.) were selected for the experimental study. Animal were randomly allocated to four groups (Group I-normal control; Group II-model control group; Group III-Pioglitazone treated group; Group IV-Diltiazem treated group). Reduction in total protein and soluble protein was significantly higher with Pioglitazone treatment at all stage of nuclear cataract of model control. Whereas Diltiazem treatment prevented the reduction in total protein and soluble protein at all stages of nuclear cataract of model control suggesting a delay in the formation of high molecular weight protein aggregates as compared to model control. The total protein and soluble protein concentration in Diltiazem treated groups were increased as compared to model control but were significantly lower than normal control at all stages of nuclear cataract of model control, suggests that Diltiazem delayed the occurrence of changes in protein concentration that cause cataract but did not prevent the occurrence of cataract....
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